Adjusting one's set points is essential to long-term weight loss. To do this, you must eliminate fat cells and diminish those remaining. When it comes to losing weight for the long term, four main aspects are intertwined. Consuming a low-fat diet with a fair number of calories prevents considerable fat from building up in one fat cell. Additionally, frequent physical exercise is necessary to burn off excess fat. Healthy weight and healthy preferences prevent hypertension, PCOS, cancer, organ level damage, obesity, diabetes, CVD, irritable bowel syndrome, eating disorders, etc.